Even the best monkey sometimes drops the sapodilla

Al mejor mono se le cae el zapote. 

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The sapodilla, locally known as the zapote, is a large, sweet fruit. Monkeys love them. But even an able-handed primate has been known to drop one from time to time. Hence, this is the equivalent of, “Nobody’s perfect.”  For example: “Este desacierto pone en evidencia que al mejor mono se le cae el zapote, que somos humanos y nos equivocamos.”  OR  “This miscalculation makes it clear that  nobody’s perfectWe are humans and we make mistakes.”

For more dichos like this, check out Lee Jamison’s Nicaraguan Spanish: Speak Like a Native.